Ή ἀνακάλυψη ἑνός γυναικείου κορμοῦ στό τεγεατικό μουσεῖο ὁδηγεί στήν ἀναγνώριση ἑνός ἰδιόχειρου ἔργου τοῦ Σκόπα : τῆς Ὑγείας πού, μαζί μέ τόν Ἀσκληπιό, πλαισίωνε τό λατρευτικό ἄγαλμα τῆς 'Αθηνᾶς στό ναό τῆς 'Αλέας (Παυσ. VIII, 47, 1). Ή ὑπόθεση αὐτη ὑποστηρίζεται ἀπό τήν ἐξαιρετική ποιότητα τοῦ ἔργου, τή στυλιστική του συγγένεια πρός τά γλυπτά τοῦ ναοῦ, τό μέγεθος, τή σύνθετη τεχνική τῆς κατασκευῆς του καί τήν ἄριστη διατήρηση τῆς ἐπιδερμίδας τοῦ μαρμάρου · καί ἐπιβεβαιώνεται χάρη στήν παράσταση ἑνός ντόπιου (...) ἀναθηματικού ἀνάγλυφου. Ἡ θεά εἰκονίζεται ἐδῶ μαζί μέ τόν Ἀσκληπιό καί συμφωνεῖ στίς εἰκονογραφικές λεπτομέρειες μέ τά στοιχεῖα πού μᾶς προσφέρει τό νέο γλυπτό. (shrink)

The practice of surgery requires consideration of a number of specific aspects of clinical medical ethics that are different from those most influential in other areas of medical care. The nature of surgical care alters the sense of responsibility that surgeons feel for their actions and also alters the relationship between surgeons and patients. Because surgical care requires patients to place such great trust in their surgeons, surgical informed consent must emphasize the importance of that trust. Surgeons must use innovative (...) means to solve individual patient problems even if the result is a novel operation. Surgical procedures may be altered due to the unexpected findings in the operating room and therefore surgeons must have considered how to respond in such situations. The future of surgical practice will inevitably lead to increasing ethical concerns in maintaining the ethical dimension of surgery, in allowing autonomy for trainees while maintaining patients’ safety, and in balancing surgical risks of prophylactic surgery with the genetic predisposition to develop cancer. (shrink)

Laspro et al. (2024) have articulated a number of important considerations in order for the first-in-human whole-eye transplant (WET) to be an ethically acceptable endeavor. These authors have clea...

Clinical red blood cell transfusion guidelines have been widely adopted in clinical practice, resulting in standardized transfusion practices in hospitalized patients with anemia. Standardization of transfusion practice has been welcomed by clinicians and health systems as a mechanism for reducing unnecessary, harmful, and costly practice variation that results in healthcare disparities. However, overzealously applied guidelines can have deleterious consequences for individual patients, ultimately resulting in and/or exacerbating healthcare disparities, rather than resolving them. This article provides empirical examples of the adverse (...) consequences from the well-meaning attempt to standardize transfusion practice based on clinical practice guidelines and discusses the ethical implications of standardized transfusion practice. (shrink)

There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world. This article discusses the relevance of this phenomenon, known as “drug-induced ego dissolution (DIED)”, for cognitive neuroscience, psychology and philosophy of mind. Data from self-report questionnaires suggest that three neuropharmacological classes of drugs can induce ego dissolution: classical psychedelics, dissociative anesthetics and agonists of the kappa opioid (...) receptor (KOR). While these substances act on different neurotransmitter receptors, they all produce strong subjective effects that can be compared to the symptoms of acute psychosis, including ego dissolution. It has been suggested that neuroimaging of DIED can indirectly shed light on the neural correlates of the self. While this line of inquiry is promising, its results must be interpreted with caution. First, neural correlates of ego dissolution might reveal the necessary neurophysiological conditions for the maintenance of the sense of self, but it is more doubtful that this method can reveal its minimally sufficient conditions. Second, it is necessary to define the relevant notion of self at play in the phenomenon of DIED. This article suggests that DIED consists in the disruption of subpersonal processes underlying the “minimal” or “embodied” self, i.e., the basic experience of being a self rooted in multimodal integration of self-related stimuli. This hypothesis is consistent with Bayesian models of phenomenal selfhood, according to which the subjective structure of conscious experience ultimately results from the optimization of predictions in perception and action. Finally, it is argued that DIED is also of particular interest for philosophy of mind. On the one hand, it challenges theories according to which consciousness always involves self-awareness. On the other hand, it suggests that ordinary conscious experience might involve a minimal kind of self-awareness rooted in multisensory processing, which is what appears to fade away during DIED. (shrink)

Many authors argue that conscious experience involves a sense of self or self-consciousness. According to the strongest version of this claim, there can be no selfless states of consciousness, namely states of consciousness that lack self-consciousness altogether. Disagreements about this claim are likely to remain merely verbal as long as the target notion of self-consciousness is not adequately specified. After distinguishing six notions of self-consciousness commonly discussed in the literature, I argue that none of the corresponding features is necessary for (...) consciousness, because there are states of consciousness in which each of them is plausibly missing. Such states can be said to be at least partially selfless, since they lack at least one of the ways in which one could be self-conscious. Furthermore, I argue that there is also preliminary empirical evidence that some states of consciousness lack all of these six putative forms of self-consciousness. Such states might be totally selfless, insofar as they lack all the ways in which one could be self-conscious. I conclude by addressing four objections to the possibility and reportability of totally selfless states of consciousness. (shrink)

Many authors claim that being conscious constitutively involves being self-conscious, or conscious of oneself. This claim appears to be threatened by reports of `selfless' episodes, or conscious episodes lacking self-consciousness, recently described in a number of pathological and nonpathological conditions. However, the credibility of these reports has in turn been challenged on the following grounds: remembering and reporting a past conscious episode as an episode that one went through is only possible if one was conscious of oneself while undergoing it. (...) Call this the Memory Challenge. This paper argues that the Memory Challenge fails to undermine the credibility to reports of selfless episodes, because it rests on problematic assumptions about episodic memory. The paper further argues that we should distinguish between several kinds of self-representation that may be involved in the process of episodic remembering, and that once we do so, it is no longer mysterious how one could accurately remember and report a selfless episode as an episode that one went through. Thus, we should take reports of this kind seriously, and view them as credible counter-examples to the claim that consciousness constitutively involves self-consciousness. (shrink)

This volume investigates the notion of reduction. Building on the idea that philosophers employ the term ‘reduction’ to reconcile diversity and directionality with unity, without relying on elimination, the book offers a powerful explication of an “ontological” notion of reduction the extension of which is (primarily) formed by properties, kinds, individuals, or processes. It argues that related notions of reduction, such as theory-reduction and functional reduction, should be defined in terms of this explication. Thereby, the book offers a coherent framework, (...) which sheds light on the history of the various reduction debates in the philosophy of science and in the philosophy of mind, and on related topics such as reduction and unification, the notion of a scientific level, and physicalism. (shrink)

The claim that consciousness constitutively involves self-consciousness has a long philosophical history, and has received renewed support in recent years. My aim in this paper is to argue that this surprisingly enduring idea is misleading at best, and insufficiently supported at worst. I start by offering an elucidatory account of consciousness, and outlining a number of foundational claims that plausibly follow from it. I subsequently distinguish two notions of self-consciousness: consciousness of oneself and consciousness of one’s experience. While “self-consciousness” is (...) often taken to refer to the former notion, the most common variant of the constitutive claim, on which I focus here, targets the latter. This claim can be further interpreted in two ways: on a deflationary reading, it falls within the scope of foundational claims about consciousness, while on an inflationary reading, it points to determinate aspects of phenomenology that are not acknowledged by the foundational claims as being aspects of all conscious mental states. I argue that the deflationary reading of the constitutive claim is plausible, but should be formulated without using a term as polysemous and suggestive as “self-consciousness”; by contrast, the inflationary reading is not adequately supported, and ultimately rests on contentious intuitions about phenomenology. I conclude that we should abandon the idea that self-consciousness is constitutive of consciousness. (shrink)

The Lotka–Volterra predator-prey-model is a widely known example of model-based science. Here we reexamine Vito Volterra’s and Umberto D’Ancona’s original publications on the model, and in particular their methodological reflections. On this basis we develop several ideas pertaining to the philosophical debate on the scientific practice of modeling. First, we show that Volterra and D’Ancona chose modeling because the problem in hand could not be approached by more direct methods such as causal inference. This suggests a philosophically insightful motivation for (...) choosing the strategy of modeling. Second, we show that the development of the model follows a trajectory from a “how possibly” to a “how actually” model. We discuss how and to what extent Volterra and D’Ancona were able to advance their model along that trajectory. It turns out they were unable to establish that their model was fully applicable to any system. Third, we consider another instance of model-based science: Darwin’s model of the origin and distribution of coral atolls in the Pacific Ocean. Darwin argued more successfully that his model faithfully represents the causal structure of the target system, and hence that it is a “how actually” model. (shrink)

In response to and as an elaboration on Robert Frodeman and Adam Briggle’s Socrates Tenured, I wish to recognize the notion of practical philosophers as both public intellectuals and as those who may find refuge in the academy in order to shed the pretense of expertise, on the one hand, and the esoteric engagement with topics irrelevant to the affairs of contemporary culture, on the other.

There is a paradox lying at the heart of the study of heredity. To understand the ways in which features are passed down from one generation to the next, we have to dig deeper and deeper into the ultimate nature of things - from organisms, to genes, to molecules. And yet as we do this, increasingly we find we are out of focus with our subjects. What has any of this to do with the living, breathing organisms with which we (...) started? Organisms are living. Molecules are not. How do we relate one to the other? In Genetic Analysis, one of the most important empirical scientists in the field in the twentieth century attempts, through a study of history and drawing on his own vast experience as a practitioner, to face this paradox head-on. His book offers a deep and innovative understanding of our ways of thinking about heredity. (shrink)

Deep learning algorithms are rapidly changing the way in which audiovisual media can be produced. Synthetic audiovisual media generated with deep learning—often subsumed colloquially under the label “deepfakes”—have a number of impressive characteristics; they are increasingly trivial to produce, and can be indistinguishable from real sounds and images recorded with a sensor. Much attention has been dedicated to ethical concerns raised by this technological development. Here, I focus instead on a set of issues related to the notion of synthetic audiovisual (...) media, its place within a broader taxonomy of audiovisual media, and how deep learning techniques differ from more traditional approaches to media synthesis. After reviewing important etiological features of deep learning pipelines for media manipulation and generation, I argue that “deepfakes” and related synthetic media produced with such pipelines do not merely offer incremental improvements over previous methods, but challenge traditional taxonomical distinctions, and pave the way for genuinely novel kinds of audiovisual media. (shrink)

This contribution demonstrates the benefits of a transatlantic history of early modern mining that encompasses both a cross-pollination of approaches and a critical reexamination of the field’s underlying assumptions. It applies to Álvaro Alonso Barba’s 1640 El arte de los metales conceptual frameworks developed by historians of early modern European mining, by scholars of labor and science in the colonial Andes, and by theorists of reader reception and scholarly practice. This analysis offers a revised understanding of Pamela Long’s model of (...) the “trading zone” as a vision of knowledge production promoted by elite Europeans and shaped by the dialogic model of knowledge production taught at European universities. Parallels between Barba and the German humanist and metallurgical author Georg Agricola (1494–1555) underscore the applicability of these findings with respect to Barba for early modern mining more generally. (shrink)

Graphical AbstractWith DNA damage being a primary anti-cancertarget, a need has arisen for the development of an approach that is a harmlessfor normal tissues but allows for cancer cell-specific cytotoxicity. Previous researchfrom K. Gurova's suggests that small compounds, namely curaxins that bind theDNA can cause chromatin instability and cell death in a cancer cell-specificmanner. In this brief perspective commentary, we investigate how the scientificcommunity has further developed this anti-cancer approach.

In his seminal Inference to the Best Explanation, Peter Lipton adopted a causal view of explanation and a broadly Millian view of how causal knowledge is obtained. This made his account vulnerable to critics who charged that Inference to the Best Explanation is merely a dressed-up version of Mill’s methods, which in the critics’ view do the real inductive work. Lipton advanced two arguments to protect Inference to the Best Explanation against this line of criticism: the problem of multiple differences (...) and the problem of inferred differences. Lipton claimed that these two problems show Mill’s method of difference to be largely unworkable unless it is embedded in an explanationist framework. Here I consider both arguments as well as the best Millian defense against them. Since the existing Millian defense is only partially successful, I will develop a new and improved account. As an integral part of the argument, I show that my solutions to the problems of multiple and inferred differences offer new insight into Lipton’s main case study: Ignaz Semmelweis’s discovery of the cause of childbed fever. I conclude that the method of difference can overcome Lipton’s challenges outside an explanationist framework. (shrink)

The ill?named debate between postmodernists and postlibertarians should be transcended; this requires the abandonment of both foundationalism and its converse, without abandoning common sense as well (which is no mean trick). Similarly, the debate over ?minimal statism? versus the planned economy is outdated. Instead of claiming to be in possession of foundations of our scientific?cum?political knowledge in broad terms, and instead of severely limiting our knowledge to given proofs, we offer the putative heuristics of critique in general and the critical (...) evaluations of contexts in particular. (shrink)

It is widely assumed that ordinary conscious experience involves some form of sense of self or consciousness of oneself. Moreover, this claim is often restricted to a ‘thin’ or ‘minimal’ notion of self-consciousness, or even ‘the simplest form of self-consciousness’, as opposed to more sophisticated forms of self-consciousness which are not deemed ubiquitous in ordinary experience. These formulations suggest that self-consciousness comes in degrees, and that individual subjects may differ with respect to the degree of self-consciousness they exhibit at a (...) given time. In this article, I critically examine this assumption. I consider what the claim that self-consciousness comes in degrees may mean, raise some challenges against the different versions of the claim, and conclude that none of them is both coherent and particularly plausible. (shrink)

Band 1. Prolegomena -- Band 2. Im Anfang erschafft Gott Himmel und Erde und den Menschen.

The honours awarded by Teos to Antiochos III and Laodike present one of the best examples of the establishment of isotheoi timai for a Hellenistic monarch by a polis . The particular interest of the Teian decree consists in the fact that it explains the symbolical significance of the ritual actions it introduced. These rituals aimed at symbolically associating Antiochos with Dionysos, with the personifications of Memory , Gratitude and Favour , with the annual cycle , and with victory. The (...) bouleuterion, where Antiochos announced his measures in favour of Teos, became a place of memory and of a continual homage to the king. The worship of the royal couple was connected with the most important public and private rituals of the Teians: the new year festival; the inauguration ceremony for the new magistrates; the introduction of the ephebes into the citizen body; the periodical first-fruit offerings; the purification rituals; and the rites of passage of women. These rituals, in part inspired by pre-existing practices , symbolically established the continual presence of the royal couple in Teos and a reciprocal relationship of gratitude and benefaction.Les honneurs rendus par Téos à Antiochos III et Laodikè offrent l’un des meilleurs exemples de la mise en place d’isotheoi timai pour un roi hellénistique de la part d’une polis . L’intérêt particulier du décret de Téos vient du fait qu’il explique la portée symbolique des actes rituels qu’il introduit. Ces rituels entendent associer symboli­quement Antiochos à Dionysos, aux personnifications de Mémoire , de Grâce et Bienveillance , au cycle de l’année , et à la victoire. Le bouleutêrion, où Antiochos a annoncé ses mesures en faveur de Téos, est devenu un lieu de mémoire et d’hommage perpétuel au roi. Le culte du couple royal était associé aux rituels publics et privés les plus importants pour les Téiens : la fête du Nouvel an, la cérémonie d’entrée en charge des nouveaux magistrats, l’entrée des éphèbes dans le corps civique, les prémices périodiques, les rites de purification et les rites de passage pour les femmes. Ces rituels, en partie inspirés de pratiques antérieures , assuraient symboli­quement la présence permanente du couple royal à Téos et une relation réciproque de gratitude et de bienveillance. (shrink)

Volume 20, Issue 8, August 2020, Page 123-125.

Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as (...) a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology. (shrink)

An important function of scientific diagrams is to identify causal relationships. This commonly relies on contrasts that highlight the effects of specific difference-makers. However, causal contrast diagrams are not an obvious and easy to recognize category because they appear in many guises. In this paper, four case studies are presented to examine how causal contrast diagrams appear in a wide range of scientific reports, from experimental to observational and even purely theoretical studies. It is shown that causal contrasts can be (...) expressed in starkly different formats, including photographs of complexly visualized macromolecules as well as line graphs, bar graphs, or plots of state spaces. Despite surface differences, however, there is a measure of conceptual unity among such diagrams. In empirical studies they generally serve not only to infer and communicate specific causal claims, but also as evidence for them. The key data of some studies is given nowhere except in the diagrams. Many diagrams show multiple causal contrasts in order to demonstrate both that an effect exists and that the effect is specific -- that is, to narrowly circumscribe the phenomenon to be explained. In a large range of scientific reports, causal contrast diagrams reflect the core epistemic claims of the researchers. (shrink)

Trata-se de texto dedicado à aplicação da interpretação diagramática de eventos da realidade tangível no modus apregoado por Charles Sanders Peirce no reino do direito tributário, utilizando-se como ferramental epistemológico para tal desiderato a fórmula de lógica simbólica criada por Paulo de Barros Carvalho chamada “regra-matriz de incidência tributária.

Developments in the sequencing of whole genomes and in simultaneously surveying many thousands of transcription and translation products of specific cells have ushered in a conceptual revolution in genetics that rationally introduces top-down, holistic analyses. This emphasized the futility of attempts to reduce genes to structurally discrete entities along the genome, and the need to return to Johannsen's definition of a gene as 'something' that refers to an invariant entity of inheritance and development. We may view genes either as generic (...) terms for units of inheritance whose referents are pragmatic ad hoc and context-dependent, or as (epistemologically) representing entities of cell functions. It is cellular functions that determine the structural referents along the DNA. Structures that happened to secure specific functions that were essential for or conducive to the survival of cells were selected for. With natural selection being the etiological background of genes as functions, genes obtain again their theoretical role as intervening variables, abstractive variables that purely 'summarize' characters. The importance of DNA sequences is that of all possible phenotypes these are the most basic ones from which we can read off the genotype directly. (shrink)